Krumholz weighs in on NSAIDs in CHF

After the previous post on NSAIDs was published earlier today, I received a comment from Harlan Krumholz on the controversy. Here it is:

“This observational study provides evidence that should give us pause about the use of NSAIDs in patients with heart failure. These patients often have compromised renal function and may be particularly vulnerable to the adverse effects of these drugs. What is most remarkable is how little we know about the safety of these common drugs in this high risk population. This study is not conclusive but is sufficient to ensure that these medications not be used without a strong indication and only in situations where there is no other choice. Meanwhile we need other studies to determine the validity of these findings.”

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