Entresto. That’s the brand name Novartis has chosen for LCZ696, its new heart failure drug that is expected to be a blockbuster. The name won’t be final until official confirmation, which comes with FDA approval. But Novartis will introduce the name for the first time this weekend in presentations at the European Society of Cardiology Heart Failure meeting in Seville, Spain. FDA approval of Entresto is expected…
Novartis’ Summer Blockbuster LCZ696 Gains A Name, Skips An Advisory Panel
May 22, 2015 by Leave a Comment
New Heart Drug From Novartis: Will It Raise The Risk of Alzheimer’s Disease?
February 9, 2015 by Leave a Comment
LCZ696 is a heart failure drug from Novartis that many observers think will gain FDA approval later this year and go on to become a blockbuster. Perhaps the biggest obstacle to the drug’s success is the fear that it might raise the risk of Alzheimer’s disease. Now a new article in a top cardiology journal lays out the detailed basis for…
An Emerging Consensus About Novartis’s New Potential Blockbuster
January 7, 2015 by Leave a Comment
Last year it became clear that Novartis had a potential blockbuster with its new heart failure drug, LCZ696, which is an angiotensin receptor- neprilysin inhibitor (ARNi) consisting of the company’s own well-known angiotensin receptor blocker valsartan (Diovan) and a novel compound, the neprilysin inhibitor sacubitiril. The results of the PARADIGM trial, which was stopped early because of a large and highly significant reduction in…
Cardiology Drugs Of The Year: New, Old, And Not-So-Funny
December 18, 2014 by 1 Comment
New Drug Of The Year: LCZ696 from Novartis Old Drug of the Year: Ezetimibe Not-So-Funny Drug of the Year: Ivabradine … Click here to read the full post on Forbes. …
PARADIGM-HF Establishes a New Paradigm for Heart Failure Treatment
August 30, 2014 by Leave a Comment
So far as I can tell the only problem with PARADIGM-HF is that the results are so good that it’s boring. Anyone interested can reasonably assume that what they hear or read about PARADIGM-HF — and cardiologists will be seeing and hearing an awful lot about it — will be overwhelmingly positive. Briefly, the trial did…
Predicting PARADIGM-HF, Or What To Expect When You’re Expecting
August 27, 2014 by Leave a Comment
The wait is almost over. For the last 5 months the most eagerly awaited trial in the cardiovascular universe has been PARADIGM-HF, the large (8,500 patient) trial of a new and novel heart failure drug from Novartis. If reality lives up to the early hope and hype, the drug, LCZ696, could completely reshape the heart failure landscape…
A New Novartis Heart Failure Drug Might Be A Blockbuster
April 1, 2014 by Leave a Comment
I try to avoid using words like “blockbuster” and “breakthrough” when writing about new drugs and treatments. I’ve been disappointed too many times. But, though they’ve been in short supply lately in cardiovascular medicine, sometimes there really are breakthroughs and blockbusters. In my career writing about cardiovascular medicine I’ve seen the introduction of the ACE…
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